BLASTP 2.2.23 [Feb-03-2010]
Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Reference for compositional score matrix adjustment:
Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala,
Aleksandr Morgulis, Alejandro A. Schäffer, and Yi-Kuo Yu (2005) "Protein database
searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.
Query= Os09g0419600 Os09g0419600|AK109320
(221 letters)
Database: rap3
52,214 sequences; 17,035,801 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
Os09g0419600 Zinc finger, RING-type domain containing protein 394 e-110
Os09g0419500 Zinc finger, RING-type domain containing protein 248 2e-66
Os09g0420000 Zinc finger, RING-type domain containing protein 239 1e-63
Os09g0420100 Zinc finger, RING-type domain containing protein 214 4e-56
Os08g0451800 Zinc finger, RING-type domain containing protein 199 2e-51
Os08g0451900 Zinc finger, RING-type domain containing protein 168 3e-42
Os09g0283600 Zinc finger, RING-type domain containing protein 153 9e-38
Os09g0435200 116 1e-26
Os12g0631200 Zinc finger, RING-type domain containing protein 110 6e-25
Os09g0434900 Zinc finger, RING-type domain containing protein 108 2e-24
Os04g0594000 RWD domain containing protein 70 8e-13
Os07g0621500 Zinc finger, RING-type domain containing protein 65 3e-11
Os09g0559000 Zinc finger, RING-type domain containing protein 64 7e-11
>Os09g0419600 Zinc finger, RING-type domain containing protein
Length = 221
Score = 394 bits (1011), Expect = e-110, Method: Compositional matrix adjust.
Identities = 198/212 (93%), Positives = 198/212 (93%)
Query: 10 AGEFYCSICMETVPGALKFSVSPCLHAFCVCCIGQYVAAKIGENTADVRCPDPGCGGGVE 69
AGEFYCSICMETVPGALKFSVSPCLHAFCVCCIGQYVAAKIGENTADVRCPDPGCGGGVE
Sbjct: 10 AGEFYCSICMETVPGALKFSVSPCLHAFCVCCIGQYVAAKIGENTADVRCPDPGCGGGVE 69
Query: 70 PESCRGVVPSEVLDRWGLLLCEAAIVARRLHCPFRDCSEPLLXXXXXXXXXXXXXXCPSC 129
PESCRGVVPSEVLDRWGLLLCEAAIVARRLHCPFRDCSEPLL CPSC
Sbjct: 70 PESCRGVVPSEVLDRWGLLLCEAAIVARRLHCPFRDCSEPLLADADGEGGGVAEAECPSC 129
Query: 130 HRLFCARCMVPWHDGVGCEEFQELGEDERGREDVMVRRLAGRERWQRCPQCRMYVEKSEG 189
HRLFCARCMVPWHDGVGCEEFQELGEDERGREDVMVRRLAGRERWQRCPQCRMYVEKSEG
Sbjct: 130 HRLFCARCMVPWHDGVGCEEFQELGEDERGREDVMVRRLAGRERWQRCPQCRMYVEKSEG 189
Query: 190 CMFMKCRCGYCFCYACASPMSKELHYCKRCKR 221
CMFMKCRCGYCFCYACASPMSKELHYCKRCKR
Sbjct: 190 CMFMKCRCGYCFCYACASPMSKELHYCKRCKR 221
>Os09g0419500 Zinc finger, RING-type domain containing protein
Length = 317
Score = 248 bits (634), Expect = 2e-66, Method: Compositional matrix adjust.
Identities = 110/212 (51%), Positives = 151/212 (71%), Gaps = 4/212 (1%)
Query: 14 YCSICMETVPGALKFSVSPCLHAFCVCCIGQYVAAKIGENTADVRCPDPGC----GGGVE 69
YC+ICMETV +F++ C HAFC C+ QY+AAK+ EN + CPDPGC GG +
Sbjct: 104 YCTICMETVDAIERFAIPGCTHAFCASCVRQYIAAKVEENVLSIGCPDPGCKDSGGGALH 163
Query: 70 PESCRGVVPSEVLDRWGLLLCEAAIVARRLHCPFRDCSEPLLXXXXXXXXXXXXXXCPSC 129
PE+CR V+P ++ RWG LC++A+ + + +CPF DCS L+ CP C
Sbjct: 164 PEACRDVIPPQLFQRWGDALCDSALSSLKFYCPFSDCSALLVDDPGDGEEAITDAECPHC 223
Query: 130 HRLFCARCMVPWHDGVGCEEFQELGEDERGREDVMVRRLAGRERWQRCPQCRMYVEKSEG 189
R+FCA+C VPWH G C EFQ+LG+DERGR+D+++R++A +WQRCP+C+MYVE+ EG
Sbjct: 224 SRMFCAQCKVPWHGGATCAEFQKLGKDERGRDDLLLRKVAKDSKWQRCPKCKMYVERVEG 283
Query: 190 CMFMKCRCGYCFCYACASPMSKELHYCKRCKR 221
C+F+ CRCG+CFCY CASPMS++ H+CK+CKR
Sbjct: 284 CVFIICRCGHCFCYLCASPMSRDNHHCKKCKR 315
>Os09g0420000 Zinc finger, RING-type domain containing protein
Length = 328
Score = 239 bits (611), Expect = 1e-63, Method: Compositional matrix adjust.
Identities = 113/213 (53%), Positives = 150/213 (70%), Gaps = 4/213 (1%)
Query: 13 FYCSICMETVPGALKFSVSPCLHAFCVCCIGQYVAAKIGENTADVRCPDPGCG-GGVEPE 71
F C ICM+ V + +F V+ C HAFC CIG YVAAK+ +N A + CPDPGC G VE
Sbjct: 116 FTCIICMDKVQASEEFLVNVCSHAFCKSCIGGYVAAKVSDNVAAIGCPDPGCEEGSVEIG 175
Query: 72 SCRGVVPSEVLDRWGLLLCEAAI-VARRLHCPFRDCSEPLLXXXXX--XXXXXXXXXCPS 128
CR +VP E+ RW + L E+++ + +CPF+DCS L+ CP
Sbjct: 176 QCRDIVPPELFGRWSVSLWESSMGETTKCYCPFKDCSAMLINDNGDGGDAEEIAETECPH 235
Query: 129 CHRLFCARCMVPWHDGVGCEEFQELGEDERGREDVMVRRLAGRERWQRCPQCRMYVEKSE 188
CHR+FCA C VPWHDG+ C+EF++LG DE+G+ED+M+++LAG+++WQRCPQCRMYVEKS
Sbjct: 236 CHRMFCASCRVPWHDGIDCKEFRKLGNDEKGKEDLMLKKLAGKKKWQRCPQCRMYVEKSA 295
Query: 189 GCMFMKCRCGYCFCYACASPMSKELHYCKRCKR 221
GC FM+CRCG+ FCY CA+PM+K +HYCK+C R
Sbjct: 296 GCTFMRCRCGFFFCYNCAAPMTKLVHYCKKCNR 328
>Os09g0420100 Zinc finger, RING-type domain containing protein
Length = 292
Score = 214 bits (545), Expect = 4e-56, Method: Compositional matrix adjust.
Identities = 95/183 (51%), Positives = 133/183 (72%), Gaps = 1/183 (0%)
Query: 15 CSICMETVPGALKFSVSPCLHAFCVCCIGQYVAAKIGENTADVRCPDPGCGGG-VEPESC 73
CS+CME + + +F+VS C HAFC CIG+YVAAKI EN A + CPDPGC G VE ++C
Sbjct: 110 CSVCMEKLQVSEQFTVSFCAHAFCNSCIGRYVAAKISENVAVIGCPDPGCEEGFVEMDTC 169
Query: 74 RGVVPSEVLDRWGLLLCEAAIVARRLHCPFRDCSEPLLXXXXXXXXXXXXXXCPSCHRLF 133
R ++P E+ DRW + LCE A+ ++ +CPF+DCS L+ CP CHR+F
Sbjct: 170 RDIIPPELFDRWSVSLCELALGEKKYYCPFKDCSALLINDNDGAEKKIRETECPHCHRMF 229
Query: 134 CARCMVPWHDGVGCEEFQELGEDERGREDVMVRRLAGRERWQRCPQCRMYVEKSEGCMFM 193
CARC VPWHDG+ C+EF++LG+DE+G ED+M ++LAG+++WQRCP C+M+V + +GC+ +
Sbjct: 230 CARCRVPWHDGIKCKEFRKLGDDEKGEEDLMFKKLAGKKKWQRCPNCKMFVSRIDGCLQI 289
Query: 194 KCR 196
KCR
Sbjct: 290 KCR 292
>Os08g0451800 Zinc finger, RING-type domain containing protein
Length = 315
Score = 199 bits (505), Expect = 2e-51, Method: Compositional matrix adjust.
Identities = 95/194 (48%), Positives = 130/194 (67%), Gaps = 5/194 (2%)
Query: 14 YCSICMETVPGALKFSVS-PCLHAFCVCCIGQYVAAKIGENTADVRCPDPGCGGGVEPES 72
+C ICM+ VP + S C HAFC C+ YV AKI E ADVRCP+ C G ++PE
Sbjct: 111 FCKICMDAVPPSAAHRASRGCDHAFCAACLAGYVGAKIQERIADVRCPEERCRGALDPEL 170
Query: 73 CRGVVPSEVLDRWGLLLCEAAIVAR-RLHCPFRDCSEPLLXXXXXXXXXXXXXXCPSCHR 131
C+G++P EV DRWG LCEA ++A R +CPF+DCS +L CPSC R
Sbjct: 171 CQGILPREVFDRWGAALCEAMVLAAPRAYCPFKDCSAMMLDDAGEAVTESE---CPSCRR 227
Query: 132 LFCARCMVPWHDGVGCEEFQELGEDERGREDVMVRRLAGRERWQRCPQCRMYVEKSEGCM 191
LFCA+C VPWH GV C +++LG+ +RG+ED++V +A ++W+RCP+C+ +VEKS+GC+
Sbjct: 228 LFCAQCAVPWHAGVDCAAYKKLGKGDRGKEDLLVVEMAKGKKWKRCPKCKYFVEKSQGCL 287
Query: 192 FMKCRCGYCFCYAC 205
+ CRCG+ FCY C
Sbjct: 288 HITCRCGFEFCYGC 301
>Os08g0451900 Zinc finger, RING-type domain containing protein
Length = 228
Score = 168 bits (425), Expect = 3e-42, Method: Compositional matrix adjust.
Identities = 92/192 (47%), Positives = 115/192 (59%), Gaps = 6/192 (3%)
Query: 15 CSICMETVPG--ALKFSVSPCLHAFCVCCIGQYVAAKI--GENTADVRCPDPGCGGGVEP 70
C ICME +P A + C HAFC C+ +V AK+ G VRCPDP CGG ++P
Sbjct: 30 CGICMEPMPPSEAHRGGGGGCAHAFCRACLAGHVRAKVESGGGAGAVRCPDPSCGGALDP 89
Query: 71 ESCRGVVPSEVLDRWGLLLCEAAIV-ARRLHCPFRDCSEPLLXXXXXXX-XXXXXXXCPS 128
E CRG +P +V +RW LCEA ARR +CP+ CSE ++ C +
Sbjct: 90 ELCRGALPGDVFERWCAALCEAMFAGARRTYCPYPGCSEMMVADADDEGCAGVTQSECQA 149
Query: 129 CHRLFCARCMVPWHDGVGCEEFQELGEDERGREDVMVRRLAGRERWQRCPQCRMYVEKSE 188
C RLFCARC VPWH GV C EF LGE ERGRED+++ + A W+RCP+CR YVEKS
Sbjct: 150 CRRLFCARCGVPWHAGVSCAEFGRLGEGERGREDLLLVQAARNGGWKRCPRCRFYVEKSH 209
Query: 189 GCMFMKCRCGYC 200
GC+ + CRC C
Sbjct: 210 GCLHITCRCAIC 221
>Os09g0283600 Zinc finger, RING-type domain containing protein
Length = 331
Score = 153 bits (387), Expect = 9e-38, Method: Compositional matrix adjust.
Identities = 79/204 (38%), Positives = 113/204 (55%), Gaps = 4/204 (1%)
Query: 13 FYCSICMETVPGALKFSVS-PCLHAFCVCCIGQYVAAKIGENTADVRCPDPGCGGGVEPE 71
+C ICM+ VP + S C HAFC C+ ++AAK+ + V CP+ GC V+PE
Sbjct: 124 LFCKICMDDVPASDAHRGSHGCAHAFCAACLAGHIAAKL-HSGGGVYCPEDGCASAVDPE 182
Query: 72 SCRGVVPSEVLDRWGLLLCEAAIVA-RRLHCPFRDCSEPLLXXXXXXXXXXXXXXCPSCH 130
C+ ++P + +RW LC A ++ R ++CPF DC+E ++ CP+C
Sbjct: 183 LCQPILPEDNFERWCAALCRAMVLGGRHVYCPFTDCAE-IIADERGGDSDGQPTECPACR 241
Query: 131 RLFCARCMVPWHDGVGCEEFQELGEDERGREDVMVRRLAGRERWQRCPQCRMYVEKSEGC 190
R FC RC V WH GV C E+ EL +RG D+ V +A RW+RCP+C+ +V++ EGC
Sbjct: 242 RRFCERCGVAWHGGVSCGEYGELAVGDRGEGDLAVVEMAKGSRWRRCPRCKFFVDRYEGC 301
Query: 191 MFMKCRCGYCFCYACASPMSKELH 214
+ CRCG FCY C H
Sbjct: 302 SHITCRCGLEFCYGCGQEWGPTGH 325
>Os09g0435200
Length = 887
Score = 116 bits (291), Expect = 1e-26, Method: Compositional matrix adjust.
Identities = 73/217 (33%), Positives = 99/217 (45%), Gaps = 17/217 (7%)
Query: 13 FYCSICMETVPGALKFSVSPCLHAFCVCCIGQYVAAKIGENTADVRCPDPGCGGG----- 67
F C IC +T+P F PC H +C+ C+ Y+ K+ E V CPDP C G
Sbjct: 438 FDCGICFDTLPMLDLFRGLPCDHKYCLECMTTYIDGKVREGAVPVACPDPECADGGDGGA 497
Query: 68 --VEPESCRGVVPSEVLDRWGLLLCEAAIV-ARRLHCPFRDCSEPLLXXXXXXXXXXXXX 124
+ PE C+ + WGL L E A+ RR +CP R C +
Sbjct: 498 GVLHPEGCKKAIDFAAFTDWGLRLAEGAVPHDRRAYCPNRRCG---ILLETSGEAEPAMA 554
Query: 125 XCPSCHRLFCARCMVPWHDGVGCEEFQELGED-ERGREDVMVRRLAGRERWQRCPQCRMY 183
CP+C L CA C W + D +G E MV++LA RW+ CP+CRM
Sbjct: 555 ACPACQHLLCATCGGEWSTADDADH-----RDCSKGPEAAMVKKLADERRWKACPKCRML 609
Query: 184 VEKSEGCMFMKCRCGYCFCYACASPMSKELHYCKRCK 220
VE++ GC M CRC FCY C + L ++C+
Sbjct: 610 VERTAGCRVMSCRCRMVFCYLCGLQIGAVLEGKEKCQ 646
>Os12g0631200 Zinc finger, RING-type domain containing protein
Length = 510
Score = 110 bits (276), Expect = 6e-25, Method: Compositional matrix adjust.
Identities = 73/210 (34%), Positives = 97/210 (46%), Gaps = 8/210 (3%)
Query: 15 CSICMETVPGALKFSVSPCLHAFCVCCIGQYVAAKIGENTADVRCPDPGCGGGVEPESCR 74
CSIC E GA V C H FC C+ Y K+ N +RCP C + C+
Sbjct: 196 CSICCEEKRGAQMIKVG-CAHTFCYSCLTSYTQEKLQTNKVPIRCPQLRCKYHISASECK 254
Query: 75 GVVPSEVLDRWGLLLCEAAIV-ARRLHCPFRDCSEPLLXXXXXXXXXXXXXX------CP 127
+P D EA R +CPF +CS L CP
Sbjct: 255 SFLPVSCYDSLERAFAEAGTSDMERFYCPFPNCSVLLDLSQHFSRASTSSQSDLNCVECP 314
Query: 128 SCHRLFCARCMVPWHDGVGCEEFQELGEDERGREDVMVRRLAGRERWQRCPQCRMYVEKS 187
CHR C C VPWH +GC+E+Q L DER D+ + RLA RW+RC +CR +E +
Sbjct: 315 ECHRDICINCGVPWHVMMGCDEYQSLPVDERDAGDLSLHRLAQNNRWRRCQRCRRMIELT 374
Query: 188 EGCMFMKCRCGYCFCYACASPMSKELHYCK 217
+GC M C CG+ FCY+C + + + C+
Sbjct: 375 QGCFHMNCWCGHEFCYSCGAEYTNGIQTCQ 404
>Os09g0434900 Zinc finger, RING-type domain containing protein
Length = 296
Score = 108 bits (271), Expect = 2e-24, Method: Compositional matrix adjust.
Identities = 75/219 (34%), Positives = 102/219 (46%), Gaps = 18/219 (8%)
Query: 11 GEFYCSICMETVPGALKFSVSP-CLHAFCVCCIGQYVAAKIGENTADVRC-----PDPGC 64
G FYC +CME +F VS C HAFCV C+ ++ A++ + V C
Sbjct: 53 GRFYCEVCMEWKLVFDRFRVSDGCPHAFCVACVVGHIEARVAAGSVPVPCLLAGGGGCSG 112
Query: 65 GGGVEPESCRGVVPSEVLDRWGLLLCEAAIVARRLHCPFRDCSEPLLXXXXXXXXXX--- 121
GG + PE C+ ++ +V DRW + LCE A+ R CP+RDC E
Sbjct: 113 GGVMHPERCKKLLDIDVFDRWCVALCERAVGPARARCPYRDCGEMAALEGEAAAAALPLR 172
Query: 122 ---XXXXCPSCHRLFCARCMVPWHDGVGCEEFQELGEDERGREDVMVRRLAGRERWQRCP 178
CP+C R FC +C PW D G G + +LA W+RCP
Sbjct: 173 AAASKASCPTCSRAFCLQCEEPWDDR------HGGGGGGDGGARCALTQLAKGREWRRCP 226
Query: 179 QCRMYVEKSEGCMFMKCRCGYCFCYACASPMSKELHYCK 217
CR ++K +GC M CRCG FCY C S + ++ CK
Sbjct: 227 SCRAMIDKIDGCKRMTCRCGTVFCYDCGSSFNPRMYSCK 265
>Os04g0594000 RWD domain containing protein
Length = 492
Score = 70.5 bits (171), Expect = 8e-13, Method: Compositional matrix adjust.
Identities = 60/217 (27%), Positives = 90/217 (41%), Gaps = 29/217 (13%)
Query: 15 CSICMETVPGALKFSVSPCLHAFCVCCIGQYVAAKIGENTA-DVRCPDPGCGGGVEPESC 73
C IC+ G+ F PC H FCV C+G + E + + CPD C + P
Sbjct: 200 CMICLSQSKGS-NFIRLPCQHLFCVKCLGTLCRMHVKEGSVFQLVCPDTKCNASIPPYVL 258
Query: 74 RGVVPSEVLDRWGLLLCEAAI--VARRLHCP--FRDCSEPLLXXXXXXXXXXXXXXCPSC 129
+ ++ + +RW L E A+ ++ ++CP C E CP C
Sbjct: 259 KRLLTEDEFERWDRLTLEKALDSMSDVVYCPRCVIGCLE----------DEDNNAQCPKC 308
Query: 130 HRLFCARCMVPWHDGVGC----EEFQE------LGEDERGREDVMVRRLAGRERWQRCPQ 179
FC+ C P H C E+ Q + E E +E + ++ L R CP+
Sbjct: 309 SFFFCSFCKEPCHPRRQCLTPEEKLQRRQASGRMSEREVAQEILNIKALYNDVRL--CPK 366
Query: 180 CRMYVEKSEGCMFMKC-RCGYCFCYACASPMSKELHY 215
CRM + K+ GC M C CG FC+ C + H+
Sbjct: 367 CRMAISKTAGCNKMVCGNCGQFFCFRCGKAIKGYDHF 403
>Os07g0621500 Zinc finger, RING-type domain containing protein
Length = 419
Score = 65.1 bits (157), Expect = 3e-11, Method: Compositional matrix adjust.
Identities = 48/182 (26%), Positives = 79/182 (43%), Gaps = 9/182 (4%)
Query: 28 FSVSPCLHAFCVCC-IGQYVAAKIGENTADVRCPDPGCGGGVEPESCRGVVPSEVLD--- 83
F + C H FC+ C + Q +A + + C GC + R ++ SE L+
Sbjct: 222 FKLESCGHVFCLTCLVDQCESALKSHDGFPLCCLKNGCKKQLLVVDLRSLLSSEKLEELF 281
Query: 84 RWGLLLCEAAIVARRLHCPFRDCSEPLLXXXXXXXXXXXXXXCPSCHRLFCARCMVPWHD 143
R L A+ + CP DC P + C +C C +C + +H
Sbjct: 282 RASLRAFVASNAGKYRFCPTPDC--PSIYQVAAADAESKPFVCGACFVEICNKCHLEYHP 339
Query: 144 GVGCEEFQELGEDERGREDVMVRRLAGRERWQRCPQCRMYVEKSEGCMFMKCRCGYCFCY 203
+ CE ++E ED ++ G+E + CP C +EK++GC ++C+CG C+
Sbjct: 340 FISCEAYKEYKEDPDA---TLLEWRKGKENVKVCPSCHFTIEKADGCNHVECKCGSHICW 396
Query: 204 AC 205
AC
Sbjct: 397 AC 398
>Os09g0559000 Zinc finger, RING-type domain containing protein
Length = 525
Score = 64.3 bits (155), Expect = 7e-11, Method: Compositional matrix adjust.
Identities = 59/200 (29%), Positives = 80/200 (40%), Gaps = 11/200 (5%)
Query: 15 CSICMETVPGALKFSVSPCLHAFCVCCIGQYVAAKIGENT--ADVRCPDPGCGGGVEPES 72
C+IC + S C H +CV C YV A +G+ +RCPDP C V E
Sbjct: 133 CAICFDVFDTGGMRSAG-CSHFYCVSCWRGYVRAAVGDGARCLSLRCPDPSCPAAVVREL 191
Query: 73 CRGVVPSEVLDRWGLLLCEAAI--VARRLHCPFRDCSEPLLXXXXXXXXXXXXXXCPSCH 130
V E +R+G + + A CP CS + C SC
Sbjct: 192 VDAVADGEDRERFGWFALRSYVEESAGMRWCPGPGCSRAVEFVGGGDGEESSEVFC-SCG 250
Query: 131 RLFCARCMVPWHDGVGCEEFQELGEDERGREDVMVRRLAGRERWQRCPQCRMYVEKSEGC 190
C RC H V C+ + E + LA + CP+CR+ +EK+ GC
Sbjct: 251 HGLCWRCGEEAHRPVSCKTVAKWVEKNSSESETATWLLAHT---KHCPKCRLPIEKNLGC 307
Query: 191 MFMKCR--CGYCFCYACASP 208
M M CR C + FC+ C P
Sbjct: 308 MHMTCRPPCLHEFCWICLKP 327
Database: rap3
Posted date: Nov 19, 2010 6:03 PM
Number of letters in database: 17,035,801
Number of sequences in database: 52,214
Lambda K H
0.330 0.143 0.522
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 52214
Number of Hits to DB: 8,356,213
Number of extensions: 361120
Number of successful extensions: 1604
Number of sequences better than 1.0e-10: 19
Number of HSP's gapped: 1558
Number of HSP's successfully gapped: 19
Length of query: 221
Length of database: 17,035,801
Length adjustment: 97
Effective length of query: 124
Effective length of database: 11,971,043
Effective search space: 1484409332
Effective search space used: 1484409332
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.8 bits)
S2: 154 (63.9 bits)