BLASTP 2.2.23 [Feb-03-2010]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Reference for compositional score matrix adjustment:
Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala,
Aleksandr Morgulis, Alejandro A. Schäffer, and Yi-Kuo Yu (2005) "Protein database
searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.

Query= Os03g0425600 Os03g0425600|Os03g0425600
         (465 letters)

Database: rap3 
           52,214 sequences; 17,035,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

Os03g0425600  Similar to UDP-glucose dehydrogenase                950   0.0  
Os12g0443500  Similar to UDP-glucose 6-dehydrogenase (EC 1.1...   848   0.0  
Os03g0757900  Similar to UDP-glucose 6-dehydrogenase (EC 1.1...   847   0.0  
Os12g0443600  Similar to UDP-glucose 6-dehydrogenase (EC 1.1...   843   0.0  
Os03g0604200  Similar to UDP-glucose dehydrogenase                817   0.0  
Os04g0581600  Similar to UDP-glucose dehydrogenase                140   2e-33
Os03g0147150                                                      132   4e-31
>Os03g0425600 Similar to UDP-glucose dehydrogenase
          Length = 465

 Score =  950 bits (2456), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 465/465 (100%), Positives = 465/465 (100%)

Query: 1   MAVIALKCPDVEVVVVDISAARIDAWNSDALPIYEPGLDDVVRRCRGRNLFFSSDVERHV 60
           MAVIALKCPDVEVVVVDISAARIDAWNSDALPIYEPGLDDVVRRCRGRNLFFSSDVERHV
Sbjct: 1   MAVIALKCPDVEVVVVDISAARIDAWNSDALPIYEPGLDDVVRRCRGRNLFFSSDVERHV 60

Query: 61  GEADIVFVSVNTPTKARGLGAGKAADLTYWESAARMIAAVATSDKVVVEKSTVPVKTAEA 120
           GEADIVFVSVNTPTKARGLGAGKAADLTYWESAARMIAAVATSDKVVVEKSTVPVKTAEA
Sbjct: 61  GEADIVFVSVNTPTKARGLGAGKAADLTYWESAARMIAAVATSDKVVVEKSTVPVKTAEA 120

Query: 121 IEKILDHNGRDGVGFQILSNPEFLAEGTAIRDLLAPDRVLIGGRETAAGRAAVQALKDVY 180
           IEKILDHNGRDGVGFQILSNPEFLAEGTAIRDLLAPDRVLIGGRETAAGRAAVQALKDVY
Sbjct: 121 IEKILDHNGRDGVGFQILSNPEFLAEGTAIRDLLAPDRVLIGGRETAAGRAAVQALKDVY 180

Query: 181 TRWVPEERILTTNLWSAELSKLAANAFLAQRISSVNAMSALCEATGADVAEVAYAVGKDS 240
           TRWVPEERILTTNLWSAELSKLAANAFLAQRISSVNAMSALCEATGADVAEVAYAVGKDS
Sbjct: 181 TRWVPEERILTTNLWSAELSKLAANAFLAQRISSVNAMSALCEATGADVAEVAYAVGKDS 240

Query: 241 RIGAKFLNASVGFGGSCFQKDILNLVYICECNGLPEVANYWKQVIKINDYQKSRFVNRVV 300
           RIGAKFLNASVGFGGSCFQKDILNLVYICECNGLPEVANYWKQVIKINDYQKSRFVNRVV
Sbjct: 241 RIGAKFLNASVGFGGSCFQKDILNLVYICECNGLPEVANYWKQVIKINDYQKSRFVNRVV 300

Query: 301 SSMFNTVAGKKIAVLGFAFKKDTGDTRETPAIDVCKGLIGDKAKVSIYDPQVTEDQVQRD 360
           SSMFNTVAGKKIAVLGFAFKKDTGDTRETPAIDVCKGLIGDKAKVSIYDPQVTEDQVQRD
Sbjct: 301 SSMFNTVAGKKIAVLGFAFKKDTGDTRETPAIDVCKGLIGDKAKVSIYDPQVTEDQVQRD 360

Query: 361 LAMSKFDWDHPVHLQPMSPTAIKQVSVAWDAYEAARAAHGVCILTEWDEFRSLDYARIYG 420
           LAMSKFDWDHPVHLQPMSPTAIKQVSVAWDAYEAARAAHGVCILTEWDEFRSLDYARIYG
Sbjct: 361 LAMSKFDWDHPVHLQPMSPTAIKQVSVAWDAYEAARAAHGVCILTEWDEFRSLDYARIYG 420

Query: 421 GMQKPAFVFDGRNVVDAEKLREIGFIVYSIGKPLDAWLKDMPAVA 465
           GMQKPAFVFDGRNVVDAEKLREIGFIVYSIGKPLDAWLKDMPAVA
Sbjct: 421 GMQKPAFVFDGRNVVDAEKLREIGFIVYSIGKPLDAWLKDMPAVA 465
>Os12g0443500 Similar to UDP-glucose 6-dehydrogenase (EC 1.1.1.22) (UDP-Glc
           dehydrogenase) (UDP-GlcDH) (UDPGDH)
          Length = 480

 Score =  848 bits (2191), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 403/465 (86%), Positives = 434/465 (93%), Gaps = 1/465 (0%)

Query: 1   MAVIALKCPDVEVVVVDISAARIDAWNSDALPIYEPGLDDVVRRCRGRNLFFSSDVERHV 60
           MAVIALKCP +EVVVVDIS  RIDAWNS+ LPIYEPGLD+VV+ CRGRNLFFS+DVE+HV
Sbjct: 17  MAVIALKCPAIEVVVVDISKPRIDAWNSEQLPIYEPGLDEVVKECRGRNLFFSTDVEKHV 76

Query: 61  GEADIVFVSVNTPTKARGLGAGKAADLTYWESAARMIAAVATSDKVVVEKSTVPVKTAEA 120
            EA+I+FVSVNTPTK RGLGAGKAADLTYWESAARMIA V+ SDK+VVEKSTVPVKTAEA
Sbjct: 77  AEANIIFVSVNTPTKTRGLGAGKAADLTYWESAARMIADVSKSDKIVVEKSTVPVKTAEA 136

Query: 121 IEKILDHNGRDGVGFQILSNPEFLAEGTAIRDLLAPDRVLIGGRETAAGRAAVQALKDVY 180
           IEKIL HN + G+ +QILSNPEFLAEGTAI DL  PDRVLIGGRET  G+ AVQALK+VY
Sbjct: 137 IEKILTHNSK-GINYQILSNPEFLAEGTAIEDLFKPDRVLIGGRETPEGKKAVQALKEVY 195

Query: 181 TRWVPEERILTTNLWSAELSKLAANAFLAQRISSVNAMSALCEATGADVAEVAYAVGKDS 240
             WVPE+RI+TTNLWSAELSKLAANAFLAQRISSVNA+SALCEATGA+VAEVAY+VGKDS
Sbjct: 196 AHWVPEDRIITTNLWSAELSKLAANAFLAQRISSVNAISALCEATGANVAEVAYSVGKDS 255

Query: 241 RIGAKFLNASVGFGGSCFQKDILNLVYICECNGLPEVANYWKQVIKINDYQKSRFVNRVV 300
           RIG KFLNASVGFGGSCFQKDILNLVYICECNGLPEVANYWKQVIKINDYQKSRFVNRVV
Sbjct: 256 RIGPKFLNASVGFGGSCFQKDILNLVYICECNGLPEVANYWKQVIKINDYQKSRFVNRVV 315

Query: 301 SSMFNTVAGKKIAVLGFAFKKDTGDTRETPAIDVCKGLIGDKAKVSIYDPQVTEDQVQRD 360
           SSMFNTV+GKKIAVLGFAFKKDTGDTRETPAIDVC GL+GDKA++SIYDPQVTEDQ+QRD
Sbjct: 316 SSMFNTVSGKKIAVLGFAFKKDTGDTRETPAIDVCHGLLGDKAQISIYDPQVTEDQIQRD 375

Query: 361 LAMSKFDWDHPVHLQPMSPTAIKQVSVAWDAYEAARAAHGVCILTEWDEFRSLDYARIYG 420
           LAMSKFDWDHP+HLQP SPTA KQVSV WDAYEA + AHGVCILTEWDEF++LDY +I+ 
Sbjct: 376 LAMSKFDWDHPMHLQPTSPTAFKQVSVVWDAYEATKGAHGVCILTEWDEFKTLDYQKIFD 435

Query: 421 GMQKPAFVFDGRNVVDAEKLREIGFIVYSIGKPLDAWLKDMPAVA 465
            MQKPAFVFDGRNVVDAEKLREIGFIVYSIGKPLDAWLKDMPAVA
Sbjct: 436 NMQKPAFVFDGRNVVDAEKLREIGFIVYSIGKPLDAWLKDMPAVA 480
>Os03g0757900 Similar to UDP-glucose 6-dehydrogenase (EC 1.1.1.22) (UDP-Glc
           dehydrogenase) (UDP-GlcDH) (UDPGDH)
          Length = 480

 Score =  847 bits (2189), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 404/465 (86%), Positives = 431/465 (92%), Gaps = 1/465 (0%)

Query: 1   MAVIALKCPDVEVVVVDISAARIDAWNSDALPIYEPGLDDVVRRCRGRNLFFSSDVERHV 60
           MAVIALKCP +EVVVVDIS  RIDAWNS+ LPIYEPGLD+VV+ CRGRNLFFS+DVE+HV
Sbjct: 17  MAVIALKCPAIEVVVVDISKPRIDAWNSEQLPIYEPGLDEVVKECRGRNLFFSTDVEKHV 76

Query: 61  GEADIVFVSVNTPTKARGLGAGKAADLTYWESAARMIAAVATSDKVVVEKSTVPVKTAEA 120
            EADI+FVSVNTPTK RGLGAGKAADLTYWESAARMIA V+ SDK+VVEKSTVPVKTAEA
Sbjct: 77  AEADIIFVSVNTPTKTRGLGAGKAADLTYWESAARMIADVSKSDKIVVEKSTVPVKTAEA 136

Query: 121 IEKILDHNGRDGVGFQILSNPEFLAEGTAIRDLLAPDRVLIGGRETAAGRAAVQALKDVY 180
           IEKIL HN + G+ +QILSNPEFLAEGTAI DL  PDRVLIGGRETA GR AVQALK VY
Sbjct: 137 IEKILTHNSK-GINYQILSNPEFLAEGTAIDDLFKPDRVLIGGRETAEGRKAVQALKSVY 195

Query: 181 TRWVPEERILTTNLWSAELSKLAANAFLAQRISSVNAMSALCEATGADVAEVAYAVGKDS 240
             WVPE+RI+TTNLWSAELSKLAANAFLAQRISSVNA+SALCEATGA+V EVAYAVGKDS
Sbjct: 196 AHWVPEDRIITTNLWSAELSKLAANAFLAQRISSVNAISALCEATGANVTEVAYAVGKDS 255

Query: 241 RIGAKFLNASVGFGGSCFQKDILNLVYICECNGLPEVANYWKQVIKINDYQKSRFVNRVV 300
           RIG KFLNASVGFGGSCFQKDILNLVYICECNGLPEVANYWKQVIKINDYQKSRFVNRVV
Sbjct: 256 RIGPKFLNASVGFGGSCFQKDILNLVYICECNGLPEVANYWKQVIKINDYQKSRFVNRVV 315

Query: 301 SSMFNTVAGKKIAVLGFAFKKDTGDTRETPAIDVCKGLIGDKAKVSIYDPQVTEDQVQRD 360
           SSMFNTV+GKKIAVLGFAFKKDTGDTRETPAIDVC GL+GDKA++SIYDPQVTEDQ+QRD
Sbjct: 316 SSMFNTVSGKKIAVLGFAFKKDTGDTRETPAIDVCHGLLGDKAQISIYDPQVTEDQIQRD 375

Query: 361 LAMSKFDWDHPVHLQPMSPTAIKQVSVAWDAYEAARAAHGVCILTEWDEFRSLDYARIYG 420
           LAM KFDWDHP+HLQP SPTA KQVSV WDAYEA + AHG+CILTEWDEF++LDY +IY 
Sbjct: 376 LAMGKFDWDHPMHLQPTSPTAFKQVSVVWDAYEATKNAHGLCILTEWDEFKTLDYQKIYD 435

Query: 421 GMQKPAFVFDGRNVVDAEKLREIGFIVYSIGKPLDAWLKDMPAVA 465
            MQKPAFVFDGRNVVD EKLREIGFIVYSIGKPLDAWLKDMPAVA
Sbjct: 436 NMQKPAFVFDGRNVVDPEKLREIGFIVYSIGKPLDAWLKDMPAVA 480
>Os12g0443600 Similar to UDP-glucose 6-dehydrogenase (EC 1.1.1.22) (UDP-Glc
           dehydrogenase) (UDP-GlcDH) (UDPGDH)
          Length = 480

 Score =  843 bits (2177), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 399/465 (85%), Positives = 432/465 (92%), Gaps = 1/465 (0%)

Query: 1   MAVIALKCPDVEVVVVDISAARIDAWNSDALPIYEPGLDDVVRRCRGRNLFFSSDVERHV 60
           MAVIALKCP +EVVVVDIS  R+DAWNSD LPIYEPGLD+VV+ CRGRNLFFS+DVE+HV
Sbjct: 17  MAVIALKCPAIEVVVVDISKPRVDAWNSDQLPIYEPGLDEVVKECRGRNLFFSTDVEKHV 76

Query: 61  GEADIVFVSVNTPTKARGLGAGKAADLTYWESAARMIAAVATSDKVVVEKSTVPVKTAEA 120
            EADI+FVSVNTPTK RGLGAGKAADLTYWESAARMIA V+ SDK+VVEKSTVPVKTAEA
Sbjct: 77  AEADIIFVSVNTPTKTRGLGAGKAADLTYWESAARMIADVSKSDKIVVEKSTVPVKTAEA 136

Query: 121 IEKILDHNGRDGVGFQILSNPEFLAEGTAIRDLLAPDRVLIGGRETAAGRAAVQALKDVY 180
           IEKIL HN + G+ +QILSNPEFLAEGTAI DL  PDRVLIGGRET  G+ AVQALK+VY
Sbjct: 137 IEKILTHNSK-GINYQILSNPEFLAEGTAIEDLFKPDRVLIGGRETPEGKKAVQALKEVY 195

Query: 181 TRWVPEERILTTNLWSAELSKLAANAFLAQRISSVNAMSALCEATGADVAEVAYAVGKDS 240
             WVPE+RI+TTNLWSAELSKLAANAFLAQRISSVNA+SALCEATGA+V+EVAYAVGKD+
Sbjct: 196 AHWVPEDRIITTNLWSAELSKLAANAFLAQRISSVNAISALCEATGANVSEVAYAVGKDT 255

Query: 241 RIGAKFLNASVGFGGSCFQKDILNLVYICECNGLPEVANYWKQVIKINDYQKSRFVNRVV 300
           RIG KFLNASVGFGGSCFQKDILNLVYICECNGLPEVANYWKQVIKINDYQKSRFVNRVV
Sbjct: 256 RIGPKFLNASVGFGGSCFQKDILNLVYICECNGLPEVANYWKQVIKINDYQKSRFVNRVV 315

Query: 301 SSMFNTVAGKKIAVLGFAFKKDTGDTRETPAIDVCKGLIGDKAKVSIYDPQVTEDQVQRD 360
           +SMFNTV+GKKIAVLGFAFKKDTGDTRETPAIDVC GL+GDKA++SIYDPQVTEDQ+QRD
Sbjct: 316 ASMFNTVSGKKIAVLGFAFKKDTGDTRETPAIDVCHGLLGDKAQISIYDPQVTEDQIQRD 375

Query: 361 LAMSKFDWDHPVHLQPMSPTAIKQVSVAWDAYEAARAAHGVCILTEWDEFRSLDYARIYG 420
           L+M+KFDWDHP HLQP SPTA KQVSV WDAYEA + AHG+CILTEWDEF++LDY RI+ 
Sbjct: 376 LSMAKFDWDHPRHLQPTSPTAFKQVSVVWDAYEATKGAHGLCILTEWDEFKTLDYQRIFD 435

Query: 421 GMQKPAFVFDGRNVVDAEKLREIGFIVYSIGKPLDAWLKDMPAVA 465
            MQKPAFVFDGRNVVD EKLREIGFIVYSIGKPLDAWLKDMPAVA
Sbjct: 436 NMQKPAFVFDGRNVVDPEKLREIGFIVYSIGKPLDAWLKDMPAVA 480
>Os03g0604200 Similar to UDP-glucose dehydrogenase
          Length = 482

 Score =  817 bits (2111), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 391/466 (83%), Positives = 427/466 (91%), Gaps = 1/466 (0%)

Query: 1   MAVIALKCPDVEVVVVDISAARIDAWNSDALPIYEPGLDDVVRRCRGRNLFFSSDVERHV 60
           MAVIALKCPDVEVVVVDISA RI+ WNS+ LPIYEPGLDDVVR+CRGRNLFFS+DVERHV
Sbjct: 17  MAVIALKCPDVEVVVVDISAPRIEGWNSERLPIYEPGLDDVVRQCRGRNLFFSTDVERHV 76

Query: 61  GEADIVFVSVNTPTKARGLGAGKAADLTYWESAARMIAAVATSDKVVVEKSTVPVKTAEA 120
            +A IVFVSVNTPTK RGLGAGKAADLTYWESAAR+IA V+ SDK+VVEKSTVPVKTAEA
Sbjct: 77  ADAGIVFVSVNTPTKTRGLGAGKAADLTYWESAARIIADVSRSDKIVVEKSTVPVKTAEA 136

Query: 121 IEKILDHNGRDG-VGFQILSNPEFLAEGTAIRDLLAPDRVLIGGRETAAGRAAVQALKDV 179
           IEKIL HN + G + +QILSNPEFLAEGTAI+DL +PDRVLIGGRET  GRAAV ALK +
Sbjct: 137 IEKILAHNSKGGNIRYQILSNPEFLAEGTAIQDLFSPDRVLIGGRETPEGRAAVAALKSI 196

Query: 180 YTRWVPEERILTTNLWSAELSKLAANAFLAQRISSVNAMSALCEATGADVAEVAYAVGKD 239
           Y RWVP++RI+TTNLWSAELSKLAANAFLAQRISSVNA+SALCEATGADV EVA ++GKD
Sbjct: 197 YARWVPDDRIITTNLWSAELSKLAANAFLAQRISSVNAISALCEATGADVTEVANSIGKD 256

Query: 240 SRIGAKFLNASVGFGGSCFQKDILNLVYICECNGLPEVANYWKQVIKINDYQKSRFVNRV 299
           SRIG +FL+ASVGFGGSCFQKDILNLVYICEC GLPEVANYW QVI+INDYQKSRFVNRV
Sbjct: 257 SRIGPRFLSASVGFGGSCFQKDILNLVYICECYGLPEVANYWHQVIRINDYQKSRFVNRV 316

Query: 300 VSSMFNTVAGKKIAVLGFAFKKDTGDTRETPAIDVCKGLIGDKAKVSIYDPQVTEDQVQR 359
           VSSMFNTVAGKK+AVLGFAFKKDTGDTRETPAIDVCKGL+GDKA VSIYDPQVTE+QVQR
Sbjct: 317 VSSMFNTVAGKKVAVLGFAFKKDTGDTRETPAIDVCKGLVGDKAVVSIYDPQVTEEQVQR 376

Query: 360 DLAMSKFDWDHPVHLQPMSPTAIKQVSVAWDAYEAARAAHGVCILTEWDEFRSLDYARIY 419
           DL M+KFDWDHP HLQPMSP++ K V+V+WDAYEAAR AH VCILTEWDEFR LDY R+Y
Sbjct: 377 DLVMNKFDWDHPRHLQPMSPSSAKHVAVSWDAYEAARGAHAVCILTEWDEFRRLDYQRMY 436

Query: 420 GGMQKPAFVFDGRNVVDAEKLREIGFIVYSIGKPLDAWLKDMPAVA 465
             M KPAF+FDGRNVVD +KLR IGF+VYSIGKPLD WL+DMPAVA
Sbjct: 437 DAMHKPAFLFDGRNVVDPDKLRRIGFVVYSIGKPLDHWLRDMPAVA 482
>Os04g0581600 Similar to UDP-glucose dehydrogenase
          Length = 219

 Score =  140 bits (354), Expect = 2e-33,   Method: Compositional matrix adjust.
 Identities = 87/167 (52%), Positives = 105/167 (62%), Gaps = 10/167 (5%)

Query: 86  DLTYWESAARMIAAVATSDKVVVEKSTVPVKTAEAIEKILDHNGRDGVGFQILSNPEFLA 145
           DL YWESAARMI   + S KVVVEKSTVP        +               S+     
Sbjct: 20  DLAYWESAARMIVDASRSGKVVVEKSTVPSGRPRPSRRSSRTTPMSS------SSRCSPT 73

Query: 146 EGTAIRDLLAPDRVLIGGRETAAGRAAVQALKDVYTRWVPEERILTTNLWSAELSKLAAN 205
             +  R   +   VLIGGR+TAA    VQALKD+Y +WVP +RI+TTNLWSAELSKLA N
Sbjct: 74  RSSWRRSRPSLTCVLIGGRDTAA----VQALKDMYAQWVPVDRIVTTNLWSAELSKLAVN 129

Query: 206 AFLAQRISSVNAMSALCEATGADVAEVAYAVGKDSRIGAKFLNASVG 252
           AFLAQR+SSVNA+SALCEATGAD+ EVA    + +++  +   ASVG
Sbjct: 130 AFLAQRVSSVNAISALCEATGADITEVATGAAQRAQVQLRRATASVG 176
>Os03g0147150 
          Length = 179

 Score =  132 bits (333), Expect = 4e-31,   Method: Compositional matrix adjust.
 Identities = 82/149 (55%), Positives = 89/149 (59%), Gaps = 41/149 (27%)

Query: 96  MIAAVATSDKVVVEKSTVPVKTAEAIEKILDHNGRDGVGFQILSNPEFLAEGTAIRDLLA 155
           MIA  + S KVVVEKSTVPVKTAEAIEKIL HN             EF            
Sbjct: 1   MIADSSRSSKVVVEKSTVPVKTAEAIEKILAHNAH---------VVEF------------ 39

Query: 156 PDRVLIGGRETAAGRAAVQALKDVYTRWVPEERILTTNLWSAELSKLAANAFLAQRISSV 215
                             QALKDVY +WVP +RI+TTNLWSAELSKLA NAFL QR+SSV
Sbjct: 40  ------------------QALKDVYAQWVPVDRIITTNLWSAELSKLAVNAFLVQRVSSV 81

Query: 216 NAMSALCEATGADVAEVAYAVGKDSRIGA 244
           NA+SALCEATG DV EV  A G   R+GA
Sbjct: 82  NAISALCEATGTDVMEV--ATGAAQRLGA 108
  Database: rap3
    Posted date:  Nov 19, 2010  6:03 PM
  Number of letters in database: 17,035,801
  Number of sequences in database:  52,214
  
Lambda     K      H
   0.320    0.134    0.400 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 52214
Number of Hits to DB: 15,203,028
Number of extensions: 611495
Number of successful extensions: 1299
Number of sequences better than 1.0e-10: 7
Number of HSP's gapped: 1295
Number of HSP's successfully gapped: 7
Length of query: 465
Length of database: 17,035,801
Length adjustment: 104
Effective length of query: 361
Effective length of database: 11,605,545
Effective search space: 4189601745
Effective search space used: 4189601745
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 158 (65.5 bits)